LSD Impacts Brain Disorders to Heal

January 15, 2019

Researchers at Yale and the University of Zurich provide new insight into the psychedelic effects of LSD on the brain and potential therapeutic uses of the drug.

Psychedelic drug impacts human consciousness, particularly perception, and is responsible for remembrance in the future events. Researchers found the effects of psychedelic drug LSD on the brain and medicinal uses of the drug. They discovered that LSD is responsible to reduce the functional connections between regions of the brain governing cognitive processes and increases the sensory functional connections with the brain. The findings were published in the journal eLife (October 25, 2018).

LSD stimulates 5HT2A receptor to increase the functional connections between brain and sensory nerves. It also regulates mood and cognition. The team studied the pattern of brain signals of people who had taken LSD, using gene expression maps.

“There is a net effect of LSD on the entire brain but the effect is not uniform,” explained Alan Anticevic, assistant professor of psychiatry and psychology and co-senior author of the paper, which appears in the journal eLife.

LSD is used to treat mental health disorders such as depression while serotonin maintains the mood balance. Scientists are searching for a possible cure for schizophrenia using LSD and serotonin combination.

“Clinicians may be able to identify individual patients most likely to benefit from these drugs by looking for similar patterns of brain activity identified in the study,” siad Katrin Preller, assistant professor at the University of Zurich and visiting professor at Yale and lead author of the study.


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